Summary
Prof Jim Crawley is a Professor of Haemostasis in the Centre for Haematology within the Department of Immunology & Inflammation.
He graduated from Durham University in with a BSc in Molecular Biology & Biochemistry, and obtained his PhD from Imperial College London in 2001. He joined the Haematology Department in 2002 as a post-doc, and was appointed to a fast-track to Lecturer scheme in 2005. In 2006 he was awarded a BHF-funded basic science Fellowship. In 2010, Jim was promoted to Senior Lecturer and to Reader in 2013. His research interests include structure/function analyses of various proteins involved in haemostasis/thrombosis, including ADAMTS13, VWF, TFPI, protein S and SLC44A2.
Further details are available from the Haemostasis Lab Homepage
Selected Publications
Journal Articles
Constantinescu-Bercu A, Grassi L, Frontini M, et al., 2020, Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2, Elife, Vol:9, ISSN:2050-084X
Petri A, Kim HJ, Xu Y, et al., 2019, Crystal structure and substrate-induced activation of ADAMTS13, Nature Communications, Vol:10, ISSN:2041-1723
de Groot R, Lane DA, Crawley JTB, 2015, The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis, Blood, Vol:125, ISSN:0006-4971, Pages:1968-1975
South K, Luken BM, Crawley JTB, et al., 2014, Conformational activation of ADAMTS13, Proceedings of the National Academy of Sciences of the United States of America, Vol:111, ISSN:0027-8424, Pages:18578-18583
Reglinska-Matveyev N, Andersson HM, Rezende SM, et al., 2014, TFPI cofactor function of protein S: essential role of the protein S SHBG-like domain, Blood, Vol:123, ISSN:0006-4971, Pages:3979-3987
Salles-Crawley II, Monkman JH, Ahnstroem J, et al., 2014, Vessel wall BAMBI contributes to hemostasis and thrombus stability., Blood, Vol:123, ISSN:0006-4971, Pages:2873-2881
Crawley JTB, Scully MA, 2013, Thrombotic thrombocytopenic purpura: basic pathophysiology and therapeutic strategies, Hematology-american Society of Hematology Education Program, ISSN:1520-4391, Pages:292-299
Ahnstroem J, Andersson HM, Hockey V, et al., 2012, Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S, Blood, Vol:120, ISSN:0006-4971, Pages:5059-5062
Salles II, Crawley JTB, 2012, Blocking VWF platelet binding to treat TTP, Blood, Vol:120, ISSN:0006-4971, Pages:3390-3392
Crawley JTB, de Groot R, 2012, Cardiovascular string theory, Blood, Vol:119, ISSN:0006-4971, Pages:2181-2182
Xiang Y, de Groot R, Crawley JTB, et al., 2011, Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), Proceedings of the National Academy of Sciences of the United States of America, Vol:108, ISSN:0027-8424, Pages:11602-11607
de Groot R, Lane DA, Crawley JTB, 2010, The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity, Blood, Vol:116, ISSN:0006-4971, Pages:3064-3072
Luken BM, Winn LYN, Emsley J, et al., 2010, The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function, Blood, Vol:115, ISSN:0006-4971, Pages:4910-4913
Andersson HM, Arantes MJ, Crawley JTB, et al., 2010, Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain, Blood, Vol:115, ISSN:0006-4971, Pages:4878-4885
Pos W, Crawley JTB, Fijnheer R, et al., 2010, An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF, Blood, Vol:115, ISSN:0006-4971, Pages:1640-1649
de Groot R, Bardhan A, Ramroop N, et al., 2009, Essential role of the disintegrin-like domain in ADAMTS13 function, Blood, Vol:113, ISSN:0006-4971, Pages:5609-5616
Gardner MD, Chion C, de Groot R, et al., 2009, A functional calcium-binding site in the metalloprotease domain of ADAMTS13, Blood, Vol:Vol. 113, Pages:1149-1157
Chion CKNK, Doggen CJM, Crawley JTB, et al., 2007, ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men, Blood, Vol:109, ISSN:0006-4971, Pages:1998-2000
Zanardelli S, Crawley JTB, Chion CKNCK, et al., 2006, ADAMTS13 substrate recognition of von Willebrand factor A2 domain, Journal of Biological Chemistry, Vol:281, Pages:1555-1563
Crawley JTB, Lam JK, Rance JB, et al., 2005, Proteolytic inactivation of ADAMTS13 by thrombin and plasmin, Blood, Vol:105, ISSN:0006-4971, Pages:1085-1093